The use of nonregular fractional factorial designs in combination toxicity studies

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The use of nonregular fractional factorial designs in combination toxicity studies.

When there is interest to study n chemicals using x dose levels each, factorial designs that require x(n) treatment groups have been put forward as one of the valuable statistical approaches for hazard assessment of chemical mixtures. Exemplary applications and cost-efficiency comparisons of full factorial designs and regular fractional factorial designs in toxicity studies can be found in Nesn...

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ژورنال

عنوان ژورنال: Food and Chemical Toxicology

سال: 2009

ISSN: 0278-6915

DOI: 10.1016/j.fct.2009.06.003